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You should first decide what exactly you want to use a peptide for, weight loss or muscle growth, then determine your dosage accordingly.
Peptides are used in an array of different ways – as monotherapy or as adjunct therapy. For example, there are several amino acids that work as agonists for the mTOR (muscle catabolic pathway), including leucine and casein. Additionally, leucine is a powerful growth factor. Other peptides are synergistic with leucine for muscle growth, but don’t synergize as well with the mTOR pathway.
The best choice for you will depend on some of the following:
Protein intake – the higher your protein intake, the better value, as peptides work better at higher circulating protein levels
Metabolic rate – the higher metabolic rate you have, the more you can benefit from using a peptide in a synergistic or additive manner
Strength level and ability to make gains on a daily basis
Amino acid distribution in muscle tissue: You may have to take a higher dosage of peptides if you’re consuming lots of amino acids in protein shakes, gels or powders
How Many Peptides Do Peptide-Based Metabolic Modulators Work?
There are only a few clinical studies to date, but they all show promising results for peptide-based metabolic modulators (MMs). Two recent trials (J. Nutrition), published in 2012 and 2013, were specifically designed to evaluate the potential of each of the three peptide metabolic modulators used by MMs – melatonin, octopamine and somatostatin. The researchers found that using a combination of amino acids (leucine, taurine, arginine or valine) or peptides (mTOR, insulin sensitivity or mTORC2) to increase energy expenditure in adults over 36 hours after strenuous exercise was as effective at boosting post-exercise thermogenesis as a common carbohydrate placebo.
However, while the potential for peptides to increase post-exercise energy expenditure is appealing, one should keep in mind that the results were so small and so the results aren’t entirely robust. The study itself is the only study of this kind and is not without flaws. Researchers also found that muscle glycogen levels increased as a result of eating two energy bars, and although the overall weight loss was more pronounced in the amino acid and peptide group (9 pounds between both groups versus only 4 pounds between the placebo and amino acid groups), the increase in glycogen levels was not statistically significant.
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